Indexing

Abstract: Cyclosporine A is an immunosuppressant used in the prevention of immune denunciation of organ transplantation and it has been reported to induce cardiotoxicity and hematological alterations. Herbal remedy has been reported to possess a potential therapeutics efficacy due to their rich antioxidant properties and Gingko Biloba supplement has been reported for its antioxidant potentials. Hence, the present study was carried out to evaluate the effect of Gingko Biloba Supplements on cardioprotective and haematological parameters of cyclosporine-induced Wistar rats. The male Wistar rats were randomly allotted to four treatment groups (n=5), the group I-II was treated with normal saline and Gingko Biloba supplement respectively, and group III-IV was administered cyclosporine alone and Gingko Biloba supplement + cyclosporine respectively for fifteen days. The Wistar rats were euthanized after treatment and the blood sample was collected for hematological and biochemical analysis. The levels of cardiac biomarkers and antioxidant enzymes such as malondialdehyde (MDA), superoxide dismutase (SOD), reduced glutathione (GSH), and catalase (CAT) were evaluated along with gross histopathological examination of the heart and pancreas. The P< 0.05 was considered to be statistically significant. The result obtained from these present shows that GBS significantly improved haematological parameters. GBS showed a protective impact in terms of improved heart and pancreas histology, as well as the antioxidant enzyme activity (CAT, SOD, GSH, and MDA).  In conclusion, the Ginkgo biloba supplementation attenuated cyclosporine toxicity by stabilizing haematological alterations and cardiac dysfunction.

Keywords: Oxidative Stress, Gingko Biloba Supplement, Cardiotoxicity and Cyclosporine.

Title: EFFECT OF GINGKO BILOBA SUPPLEMENTS ON CARDIOPROTECTIVE AND HAEMATOLOGICAL PARAMETERS OF CYCLOSPORINE-INDUCED WISTAR RATS

Author: William, Boulobellemowei Debekeme, Henrrietta Ogadimma Asuzu-Samuel

International Journal of Recent Research in Life Sciences (IJRRLS)

ISSN 2349-7823

Vol. 11, Issue 1, January 2024 - March 2024

Page No: 40-51

Paper Publications

Website: www.paperpublications.org

Published Date: 18-February-2024

Abstract: Haematological parameters are important clinical markers in determining the health and disease status of an individual. The study aims to determine some haematological parameters of some 500 Level Undergraduate students of School of Science Laboratory Technology of the University of Port Harcourt. A total of 100 (One Hundred) year 5 undergraduate students of the School of Science Laboratory Technology (SSLT), University of Port Harcourt(50 males and 50 females) were randomly recruited for this study. Structured questionnaires will be administered to obtain the sociodemographic data of the study participants. Data such as the age, sex, Department, weight and height of participants will be collated. 5mL of venous blood samples were collected from each subject through the antecubital vein following the standard procedure for venous blood collection. The blood samples were sent to the laboratory for analysis of red blood cell (RBC) count, packed cell volume (PCV), haemoglobin (Hb) concentration, white blood cell (WBC) count and differential counts such as lymphocytes, monocytes, basophils, neutrophils, and eosinophils and platelet count. Results obtained were subjected to analysis using statistical package for social sciences. 86% of our participants were between the ages of 21 to 24 years, 14% within 25 - 28 years. There were significantly higher mean values of white blood cells, lymphocyte count and monocyte count in the male undergraduate students’ than the female at p =0.001. The mean values of packed cell volume, red blood cells, haemoglobin concentration and eosinophil count were higher in the male than female respondents, but this difference was not statistically significant (p = 0.126, p = 0.557, p = 0.069 and p = 0.171 respectively). This study revealed that the undergraduate students used in this study had lower mean values of Packed cell volume (PCV), Haemoglobin (HB) concentration and Red Blood Cells (RBC) Count compared to the normal standard reference value.This study has established values for haematological parameters in apparently healthy undergraduate students’.

Keywords: Haematological, Blood, Determination, Undergraduate and Adults.

Title: DETERMINATION OF SOME HAEMATOLOGICAL PARAMETERS OF 500 LEVEL UNDERGRADUATE STUDENTS OF SCIENCE LABORATORY TECHNOLOGY OF UNIVERSITY OF PORT HARCOURT

Author: H.O. Asuzu-Samuel, Karibo Amakiri Okari

International Journal of Recent Research in Life Sciences (IJRRLS)

ISSN 2349-7823

Vol. 11, Issue 1, January 2024 - March 2024

Page No: 27-39

Paper Publications

Website: www.paperpublications.org

Published Date: 18-February-2024

Abstract: Morphea is an uncommon cutaneous disorder characterized by thickening of the skin. It usually presents as a single or few indurated cutaneous plaques. Herein, we present a case with an unusual and generalized presentation of cutaneous morphea.

Keywords: Cutaneous disorder, Cutaneous plaques, Scleroderma, Cutaneous Morphea.

Title: Generalized and Unusual Presentation of Cutenaous Morphea: A Case Report

Author: Fahad Alsudairy, Hamad Aldahafiri, Nada Alqadri

International Journal of Recent Research in Life Sciences (IJRRLS)

ISSN 2349-7823

Vol. 11, Issue 1, January 2024 - March 2024

Page No: 23-26

Paper Publications

Website: www.paperpublications.org

Published Date: 08-February-2024

Abstract: A safe and effective vaccine is a critical tool to control the COVID-19 pandemic. However, Vaccine hesitancy presents a barrier to immunization program success and, in fact, has been identified by the World Health Organization (WHO) as one of the top 10 global health threats in containment the virus. Hence, the present study aim to evaluate the perception and acceptance of covid-19 vaccine among selected workers in Rivers State. Using the cross-sectional survey design, a sample size of 500 were randomly selected from the population of 1,665,000 inhabitants of Port Harcourt as at the time of the study. A structured questionnaire was used to obtain information for the study from the respondent.  Data obtained from the retrieved questionnaire were analyzed using IBM SPSS descriptive statistics and chi-square inferential statistics was used for the inferential statistics at 0.05 level of significance. The result revealed that participants who have heard about vaccination were most frequent with 454(98.7%), those who were willing to take the vaccine or have taken the vaccine before were  322(70%) and healthcare workers were the most frequent option to consult before taking the vaccine when in doubt 243(53.9%).Furthermore, the healthcare workers had the highest level of acceptance, showing a proportional statistical significant at p<0.001 when compared to Civil servants and UNIPORT staff members. though there was high level of awareness of vaccine, however, vaccines perceived safety concerns and trust were associated with hesitance. Hence, the health authorities via health care providers, who were identified by the people as the most trusted source of information regarding information about COVID-19 vaccines, should design interventions in terms of awareness campaigns via all types of multimedia to spread more transparent information about the safety and efficacy of the vaccines.

Keywords: Perception, Vaccine, Corona Virus and Workers.  

Title: PERCEPTION AND ACCEPTANCE OF COVID-19 VACCINE AMONG SELECTED WORKERS IN RIVERS STATE, SOUTH-SOUTH NIGERIA

Author: H.O. Asuzu-Samuel

International Journal of Recent Research in Life Sciences (IJRRLS)

ISSN 2349-7823

Vol. 11, Issue 1, January 2024 - March 2024

Page No: 11-22

Paper Publications

Website: www.paperpublications.org

Published Date: 27-January-2024

Abstract: This study was designed to investigate the effects of Moringa oleifera leaves in the alloxan treated diabetic rats. The rats with body weights (120-200g) of either set were used for the study. Alloxan was given by single intraperitoneal injection (150mg/kg) and was administered orally, once a day for 21 days. The blood glucose, body weight and hematological parameters was evaluated in alloxan induced diabetic rats after 21 days daily treatment with Moringa oleifera leaves extract. The result of the study showed decrease in blood glucose level at the end of 21days, Moringa oleifera leaves also improved the body weight of alloxan treated rats. The result of the study proved the hypoglycemic effects of Moringa oleifera leaves in allotan treated diabetic rats. It may be due to the presence of flavoniods, which helps to speed up the natural healing process and may improve the glycemic control in diabetic rats.

Keywords: Alloxan, Hematological, Diabetic and Methanol.

Title: EFFECT OF METHANOL MORINGA OLEIFERA LEAVES EXTRACT ON HEMATOLOGICAL PARAMETERS OF ALLOXAN INDUCED DIABETIC WISTAR RATS

Author: H.O. Asuzu-Samuel, Karibo Amakiri Okari

International Journal of Recent Research in Life Sciences (IJRRLS)

ISSN 2349-7823

Vol. 11, Issue 1, January 2024 - March 2024

Page No: 6-10

Paper Publications

Website: www.paperpublications.org

Published Date: 27-January-2024

Abstract: Plant cell, tissue and organ culture basically involve isolating a cell, tissue or organ and aseptically placing it on a nutrient medium under controlled environmental conditions, so as to obtain plant cells or whole plants from it. It was in 1902 that a German plant physiologist Habertlandt, first demonstrated totipotency of cells and tried to cultivate plant tissue and organs in vitro. He was not very successful, but his work was soon followed by other workers. The first true plants to be established via tissue culture were those of carrot and tobacco in 1939 (White, 1939, 1943).

Keywords: Plant Tissue, Organ Culture, German plant physiologist Habertlandt, carrot and tobacco.

Title: A review of Plant tissue and organ culture

Author: Dr. Ranu Shukla

International Journal of Recent Research in Life Sciences (IJRRLS)

ISSN 2349-7823

Vol. 11, Issue 1, January 2024 - March 2024

Page No: 1-5

Paper Publications

Website: www.paperpublications.org

Published Date: 06-January-2024